Edited by Sue Clark
Intensive research over the last fifteen years has yielded a vast expansion in our understanding of the role of inheritance and genetics in many cancers. Several inherited conditions have been identified which result in a high risk of various cancers; some of these were previously recognised, but the genetic basis underlying them has now been elucidated.
This knowledge is now entering the sphere of routine clinical care. This raises challenges for clinicians untrained in genetics and unfamiliar with the evolving legal and ethical issues, molecular technology and implications for disease management.
The authors are active researchers and clinicians, and many are non-geneticists who have developed expertise in inherited cancer syndromes occurring in their specialty. As well as outlining fundamental genetic principles, and describing the more common inherited cancer syndromes and their management, they have been asked to look to the future of this exciting and rapidly developing field.
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