St. Mark's Hospital is a national and international referral centre for intestinal and colorectal disorders.
As well as clinical services covering all aspects of colorectal disease and intestinal failure, it has many research interests and a very active programme of teaching and education.

St. Mark's Hospital was founded by Frederick Salmon in 1835 to treat patients with anorectal disorders. It was one of the first specialist hospitals and has played a major part in the development of colorectal disease, gastroenterology and nutrition. St. Mark's Hospital and Academic Institute together form a centre for coloproctology attracting practitioners from the UK and overseas to enable best practice to be spread to other institutions.
St. Mark's prides itself on a multidisciplinary approach to individual patients and combines both medical and surgical expertise with specialist nursing and paramedical skills.
Within the North West London Hospitals NHS Trust, St. Mark's Hospital is headed by the Clinical Director, Professor Robin Phillips. The Clinical Director is supported by the Divisional General Manager Specialist Services who together with the Dean of St Mark's Academic Institute, Professor Robin Kennedy, form the Executive of the hospital.
St. Mark's Hospital along with the Hope Hospital, Manchester, are nationally headed to provide the Intestinal Failure Service. The Intestinal Failure Service is commissioned from St. Mark's by the National Commissioning Group for Highly Specialised Services.